AnaVation is seeking an experienced Senior Information System Security Officer (ISSO) to support a mission-critical cybersecurity. This senior-level role requires expert knowledge of RMF and NIST frameworks to lead complex ATO efforts, manage high-value systems, and mentor junior security staff. The selected candidate will play a key role in safeguarding cloud-based, high-impact, and classified systems across the federal enterprise. Responsibilities include maintaining security documentation, conducting security control assessments, performing audit log and vulnerability scan reviews, collaborating with technical teams to manage risk, supporting Ongoing Authorization (OA) and continuous monitoring activities, and preparing briefings for senior leadership on system security posture and compliance metrics.