Senior Principal Scientific Developer

At Cadence, we hire and develop leaders and innovators who want to make an impact on the world of technology.

OpenEye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud-native fully integrated software-as-a-service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. OpenEye, Cadence Molecular Sciences is headquartered in Santa Fe, N.M., with offices in Boston, Mass.; Cologne, Germany; and Tokyo, Japan.

We are looking for a professional scientific software developer with deep expertise in Cheminformatics and Modeling Software Development to join our team of experts in mathematics, computational chemistry, cheminformatics, and machine learning. This highly focused team will work together to drive forward technology which leverages OpenEye’s Orion platform and scientific code base to better enable scientists in the pharmaceutical industry to reliably and efficiently solve drug discovery problems. This role will require extensive interactions with customers and OpenEye’s commercial, scientific and technical teams.

What you’ll do:

• Implement new algorithms of priority to customers based on literature or internal technical descriptions involving scientific uncertainty, hypothesis-testing and performance analysis.
• Use technical and aesthetic skills to maintain and expand chemical depiction and scientific display libraries including responsibility for understanding and properly representing chemical matter to a modern scientific standard.
• Help maintain twenty-five years of legacy C++ scientific code base.
• Explore an array of descriptor types and modeling methods to identify those most useful in explaining generated results.
• Development of cheminformatics and modeling workflows and associated infrastructure to support production-level ML featurization and tools.

What you should have (formerly requirements):

• PhD in chemistry, cheminformatics or computational chemistry or similar (or equivalent experience)
• 15+ years in the pharmaceutical, biotech or related industries (or equivalent experience)
• Expertise in python and C++, professional development skills, development toolchain knowledge
• Experience developing in a professional software environment including source control, continuous integration and continuous testing
• Deep expertise in cheminformatics toolkit programming
• Experience in and a desire to learn more about the pharmaceutical industry
• Strong desire to find practical solutions to challenging scientific and programming problems
• Demonstrated ability to work at a high level both as part of a team and independently
• Proven track record of solving complex scientific problems with elegant technical solutions

The following are a PLUS, but not required (optional):

• Experience using OEChem and RDKit to implement mission-critical professional projects
• Experience using AI-based code generation tools to prototype new functionality
• Experience using small-molecule registry systems in the biotech and pharmaceutical industry
• 3+ years’ experience in the pharmaceutical industry delivering scientific solutions to project teams