AAVantgarde Bio is seeking a self-driven Senior Statistical Programmer (Consultant) to support its rapidly advancing ophthalmology pipeline. This role involves developing, validating, and maintaining high-quality SAS programs for clinical and imaging data, ensuring data quality and scientific insight. The programmer will own deliverables end-to-end, apply deep SAS expertise, and ensure data is transformed into high-impact evidence packages for regulatory interactions and decision-making. The role requires strategic awareness and proactive problem-solving in a fast-paced biotech environment.

Must Have

• Develop, validate, and maintain high-quality SAS programs for SDTM, ADaM, TLFs, exploratory endpoints, and ophthalmology-specific analyses.
• Apply deep SAS expertise to build and maintain robust, reusable macro libraries.
• Implement standardised processes, templates, and QC frameworks.
• Own key analysis deliverables from conception through execution, ensuring accuracy and traceability.
• Deliver SDTM and ADaM datasets that meet global regulatory standards for imaging-rich ophthalmology trials.
• Develop define.xml, reviewer’s guides, metadata, and traceability documentation.
• Expert SAS programmer with strong macro development.
• Hands-on experience with CDISC SDTM and ADaM, including submission-ready documentation.
• Self-driven, proactive, and highly accountable.
• Committed to delivering exceptional quality under accelerated timelines.

Good to Have

• Proficiency in R and/or Python.
• Experience with ophthalmology or imaging-heavy datasets.
• Comfortable with reading-centre data flows, multimodal imaging pipelines, and vendor-generated endpoints.

Perks & Benefits

• Health insurance
• Psychotherapy coverage
• Sport coverage
• Learning budget
• Paid vacation days
• Paid sick leaves
• All public holidays are paid days off

Statistical Programmer | AAVantgarde Bio

Location

Remote from Poland, Spain

Employment Type

Full time

Location Type

Remote

Department

AAVantgarde Bio

GT was founded in 2019 by a former Apple, Nest, and Google executive. GT’s mission is to connect the world’s best talent with product careers offered by high-growth companies in the UK, USA, Canada, Germany, and the Netherlands.

On behalf of AAVantgarde Bio, GT is looking for Senior Statistical Programmer (Consultant) to support an advanced ophthalmology.

About the Client

AAVantgarde Bio is an international clinical-stage biotechnology company developing next-generation gene therapies for inherited retinal diseases. The company has created two proprietary technologies that enable the delivery of large genes into human cells, overcoming one of the major limitations of traditional gene therapy approaches. These platforms are already being validated in clinical trials, with the potential to expand into multiple disease areas beyond ophthalmology.

Headquartered in Milan, AAVantgarde operates with a growing international team and a strong focus on translating advanced science into real patient impact. The company was founded by Professor Alberto Auricchio, a globally recognised pioneer in gene therapy.

• Founded: 2021
• Series B startup

About the Role

We are scaling a next-generation biometrics function to support a rapidly advancing ophthalmology pipeline where speed, data quality, and scientific insight directly determine programme success.

This is a role for a self-driven Statistical Programmer who proactively owns their deliverables end-to-end and consistently delivers work of exceptional quality—often under tight, business-critical timelines.

This role suits someone who brings technical mastery in SAS and strategic awareness. You will anticipate analytical needs before they arise, shape programming frameworks that scale with our development ambitions, and ensure that clinical and imaging data are transformed into high-impact evidence packages for regulatory interactions, governance meetings, and board-level decisions.

Responsibilities:

Clinical Programming & Analysis Delivery

• Develop, validate, and maintain high-quality SAS programs for SDTM, ADaM, TLFs, exploratory endpoints, and ophthalmology-specific analyses.
• Apply deep SAS expertise to build and maintain robust, reusable macro libraries, driving cross-study standardisation and reducing cycle times.
• Implement standardised processes, templates, and QC frameworks to deliver consistent, audit-ready outputs.
• Own key analysis deliverables from conception through execution, ensuring accuracy, traceability, and readiness for high-visibility use.
• Flex outside standard hours when necessary to meet time-critical milestones (IDMC packages, rapid eligibility decisions, regulatory responses).
• Independently identify analysis gaps, data risks, and upcoming needs—proactively initiating work before requests surface.

Data Standards, Submission Readiness & Quality Governance

• Deliver SDTM and ADaM datasets that meet global regulatory standards for imaging-rich ophthalmology trials.
• Develop define.xml, reviewer’s guides, metadata, and traceability documentation with meticulous attention to detail.
• Drive macro- and process-level standardisation across programmes to ensure efficiency, reproducibility, and seamless auditability.
• Anticipate regulatory and clinical questions and design programming strategies that support defensible, submission-ready analyses.
• Ensure programming frameworks can evolve with the complexity of multimodal imaging and reading-centre data.

Strategic Collaboration & Decision Support

• Transform clinical and imaging data into crisp, decision-ready insights for senior leadership, governance committees, and board presentations.
• Partner closely with statisticians, clinical scientists, imaging vendors, and medical teams to ensure programming aligns with scientific objectives.
• Operate as a strategic contributor—not just an executor—proactively recommending analyses, visualisations, and data structures that support programme acceleration.
• Communicate technical topics clearly and confidently, tailoring the narrative to scientific, clinical, and executive audiences.

Innovation, Automation & Continuous Improvement

• Expand automation through SAS macro frameworks and version-controlled workflows.
• Lead process standardisation across the biometrics ecosystem, ensuring naming conventions, documentation formats, and QC models are consistent and scalable.
• Introduce tools and workflows that materially reduce cycle time and increase reliability, from templated analysis scripts to automated QC dashboards.
• Partner on digital biomarker integration, image-derived metrics, and advanced analytical approaches as the ophthalmology programme evolves.
• Continuously scan ahead for bottlenecks, emerging requirements, and resourcing gaps—bringing solutions before problems surface.

Essential knowledge, skills & experience:

Technical Expertise

• Expert SAS programmer with strong macro development and a track record of driving standardisation across studies.
• Proficiency in R and/or Python preferred.
• Hands-on experience with CDISC SDTM and ADaM, including submission-ready documentation.
• Experience with ophthalmology or imaging-heavy datasets strongly preferred.
• Comfortable with reading-centre data flows, multimodal imaging pipelines, and vendor-generated endpoints.

Professional Attributes

• Self-driven, proactive, and highly accountable—takes ownership without waiting to be asked.
• Natural ability to anticipate analytical needs and strategically plan ahead.
• Committed to delivering exceptional quality under accelerated timelines.
• Strong communication and storytelling skills, especially when supporting leadership and board-level deliverables.
• Thrives in a fast-moving, high-expectation biotech environment.

Success Indicators

Deliverables consistently produced at high quality, on time, and ready for inspection without rework.

Evidence of strategic foresight—programming tools, macros, and processes that anticipate future study needs.

Standardised SAS macro libraries that materially improve speed, consistency, and traceability.

High-impact analyses and visual outputs that strengthen executive and board decision-making.

A biometrics programming environment that becomes progressively more automated, scalable, and operationally excellent.

Interview Steps

1. GT interview with Recruiter

2. Technical interview

3. Final interview

We go beyond usual perks… By working with us, you will get:

• Health insurance.
• Psychotherapy coverage.
• Sport coverage.
• Learning budget.
• Paid vacation days.
• Paid sick leaves.
• All public holidays are paid days off.

GT working model:

You will work directly with a client through our Extended Team model. We try to do things differently and put our efforts into integrating you as deeply as possible into the client’s team. You work with the same tools and technologies as they do and are managed directly by the client without any intermediary in between. We help you build relationships and create an environment where you genuinely feel like a member of the client’s team. We also encourage trips to a client and join teambuilding and after-work activities. Our Extended Team model is focused on long-term projects that last over several years.

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