Research Scientist - Cell Biology

The Biosciences and Biotechnology Division within the Physical and Life Sciences Directorate LLNL is seeking to fill a position for a dedicated and hardworking Research Scientist with a background in cell biology with a cardiac focus, with demonstrated experience in advanced cellular and tissue models, toxicology, electrocardiography and in vivo assessments. In this position, you will direct and conduct advanced cell and animal biology research, contributing to our understanding tissue and cell level effects of physiological insults for mission relevant programs. Your role will involve working on defined research projects, where you will be expected to demonstrate initiative, resourcefulness, and a keen attention to detail within a multidisciplinary team of scientists. This position is in the Human Health Sciences Group in the Biosciences and Biotechnology Division.

This position requires full-time on-site presence due to the nature of the work.

You will 

• Lead and implement in vitro experiments that include both 2D and 3D rat and human cardiac cell models.
• Collaborate with other scientists for in vivo experiments.
• Utilize advanced cell and molecular biology techniques to investigate and understand mechanisms of cellular injury and repair in cardiac tissues.
• Evaluate large data sets to refine, inform, and design subsequent experiments.
• Conduct literature reviews on state-of-the-art approaches relevant to the problem being addressed.
• Train and mentor early career and technician level staff.
• Collaborate and interact with inter-organizational contacts and/or external customers.
• Prepare and present technical reports.
• Perform other duties as assigned.

• Ability to secure and maintain a U.S. DOE Q-level security clearance which requires U.S. Citizenship.
• Ph.D. in Cell Biology or related field, or the equivalent combination of education and related experience.
• Significant experience with human and rat cell cultures, with an emphasis on cardiac cells and tissue models.
• Significant experience with electrophysiology, immunostaining, flow cytometry, and multi-omics (emphasis on single-cell RNA sequencing).
• Significant experience with in vivo assessments of cardiac function including electrocardiography.
• Significant experience in elucidating mechanisms of cellular or tissue disfunction.
• Proficiency in R or equivalent for data analyses.
• Advanced understanding of statistics for longitudinal datasets.
• Practical experience with multi-omics sample preparation and analyses.
• Experience in a fast-paced environment and able to work both independently and as a team with a diverse set of scientists, engineers, and other technical and administrative staff.
• Proficient with common software (e.g., Microsoft Office applications) and able to quickly learn new software.

Qualifications We Desire

• Experience with histology and immunohistochemistry.
• Experience with hematology and clinical chemistry.

#LI-Onsite

Position Information

This is a Flexible Term appointment, which is for a definite period not to exceed six years.  If final candidate is a Career Indefinite employee, Career Indefinite status may be maintained (should funding allow).

Why Lawrence Livermore National Laboratory?

• Included in 2025 Best Places to Work by Glassdoor!
• Flexible Benefits Package
• 401(k)
• Relocation Assistance
• Education Reimbursement Program
• Flexible schedules (*depending on project needs)
• Our values - visit https://www.llnl.gov/inclusion/our-values

Security Clearance

This position requires a Department of Energy (DOE) Q-level clearance.  If you are selected, we will initiate a Federal background investigation to determine if you meet eligibility requirements for access to classified information or matter. Also, all L or Q cleared employees are subject to random drug testing.  Q-level clearance requires U.S. citizenship. 

Pre-Employment Drug Test

External applicant(s) selected for this position must pass a post-offer, pre-employment drug test. This includes testing for use of marijuana as Federal Law applies to us as a Federal Contractor.

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If you use a medical device, which pairs with a mobile device, you must still follow the rules concerning the mobile device in individual sections within Limited Areas.  Sensitive Compartmented Information Facilities require separate approval. Hearing aids without wireless capabilities or wireless that has been disabled are allowed in Limited Areas, Secure Space and Transit/Buffer Space within buildings.

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