Manager, Program Management, Strategy Execution and Transformation

At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.

Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

Position Summary:

The Program Manager will play a critical role in driving execution of the company’s most important strategic priorities. This role sits within the Strategy Execution Office (SEO) and will operate in two capacities:

(1) Program Manager: Primarily, you will drive the day-to-day planning and execution of one of our Top 12 strategic priorities (or a major workstream within one), coordinating across functions, ensuring milestones are achieved, and delivering measurable business outcomes.

(2) Portfolio Support Role: In addition to leading a specific initiative, you will contribute to the overall health and effectiveness of the strategy execution portfolio. This includes helping manage cross-initiative dependencies, supporting enterprise-level risk and issue management, driving portfolio reporting and analytics, and contributing to the continuous improvement of our operating rhythm.

This role requires strong program management discipline, cross-functional coordination skills, and the ability to operate in a dynamic, fast-moving environment. You will work closely with initiative owners and functional leaders to ensure our most critical programs stay on track, deliver value, and remain tightly aligned to our strategy.

*This person must be able to commute to our San Diego HQ 2-3 days/week.

All About You

Responsibilities:

Initiative Leadership

• Partner with initiative owners and stakeholders to define, plan, and execute strategic programs that align with enterprise goals

• Develop and maintain program scope, timelines, resource plans, and milestone tracking, ensuring alignment across functional and regional teams

• Lead the initiative’s execution rhythm, including workplans, stakeholder engagement/communication, and dependency management

• Facilitate business case development and ensure clear articulation of expected value and outcomes

• Identify and escalate key risks, issues, and decisions, and support resolution in partnership with initiative leads and the SEO

Portfolio-Level Execution Support

• Support the overall portfolio by helping drive cross-initiative visibility into dependencies, risks, capability gaps, and resource bottlenecks

• Assist in maintaining a consistent program management framework, including use of lifecycle gates, execution standards, and governance routines

• Contribute to portfolio reporting, scorecards, and KPI tracking — synthesizing initiative-level progress into executive-level insights

• Collaborate with other program managers and the SEO to drive continuous improvement in our execution model, tools, and ways of working

Listed responsibilities are an essential, but not exhaustive list, of the usual duties associated with the position. Changes to individual responsibilities may occur due to business needs.

Requirements:

• BA / BS (science, business, math or econ/finance preferred)

• 8+ years of professional experience in program & project management, business transformation, process improvement, change management, system implementation, and/or similar corporate functions

• 3+ years in cross-functional roles within a global enterprise

• PMP certification preferred

• Advanced analytical and presentation skills

• Experience building financial business cases

• Ability to engage and influence effectively at all levels and within a matrixed environment

• Ability to collaborate and communicate effectively with a diverse set of peers and stakeholders across organizational levels, functions and geographies/cultures

• Must be driven, self-motivated, well-organized and able to thrive under ambiguity

All listed requirements are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional task and responsibilities.

#LI-HYBRID

The estimated base salary range for the Manager, Program Mgmt, Strategy Execution and Transformation (Hybrid) role based in the United States of America is: $115,800 - $173,800. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. Compensation decisions are dependent on several factors including, but not limited to, an individual’s qualifications, location where the role is to be performed, internal equity, and alignment with market data. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including access to genomics sequencing, family planning, health/dental/vision, retirement benefits, and paid time off.

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact accommodations@illumina.com. To learn more, visit: https://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf. The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.